Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,​β-unsaturated imines

• Main Authors: Hao, Lin, Chen, Shaojin, Xu, Jianfeng, Tiwari, Bhoopendra, Fu, Zhenqian, Li, Tong, Lim, Jieyan, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/104154; http://hdl.handle.net/10220/19452
• Institution: Nanyang Technological University

Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic...