NHC organocatalytic formal LUMO activation of α,β-unsaturated esters for reaction with enamides
An effective wake-up call: Stable ,β-unsaturated esters were activated by the addition of a chiral N-heterocyclic carbene (NHC) organocatalyst, and the resulting reactive Michael acceptor intermediates reacted with enamide nucleophiles to furnish optically pure products (see scheme; Ts=p-toluenesulf...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/104220 http://hdl.handle.net/10220/19438 |
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| Institution: | Nanyang Technological University |
| Language: | English |