NHC-catalyzed ester activation : access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines

• المؤلفون الرئيسيون: Hao, Lin, Chuen, Chan Wei, Ganguly, Rakesh, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/104221; http://hdl.handle.net/10220/19449
• المؤسسة: Nanyang Technological University

Carboxylic esters can be readily obtained at low cost. Therefore, asymmetric catalytic activation of esters should provide useful strategies for organic synthesis. Here we report a N-heterocyclic carbene (NHC)-mediated reaction of α-aryl acetic esters with oxindole-derived α,β-unsaturated imines. Th...