Organocatalytic enantioselective γ-aminoalkylation of unsaturated ester : access to pipecolic acid derivatives
The direct γ-carbon functionalization of α,β-unsaturated esters via N-Heterocyclic Carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optical...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/104212 http://hdl.handle.net/10220/19439 |
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| Institution: | Nanyang Technological University |
| Language: | English |