Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines

Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic...

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Main Authors:	Hao, Lin, Chen, Shaojin, Xu, Jianfeng, Tiwari, Bhoopendra, Fu, Zhenqian, Li, Tong, Lim, Jieyan, Chi, Robin Yonggui
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2014
Subjects:	DRNTU::Science::Chemistry::Organic chemistry
Online Access:	https://hdl.handle.net/10356/104154 http://hdl.handle.net/10220/19452
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-104154
record_format	dspace
spelling	sg-ntu-dr.10356-1041542020-03-07T12:34:57Z Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines Hao, Lin Chen, Shaojin Xu, Jianfeng Tiwari, Bhoopendra Fu, Zhenqian Li, Tong Lim, Jieyan Chi, Robin Yonggui School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported. 2014-05-26T02:59:51Z 2019-12-06T21:27:35Z 2014-05-26T02:59:51Z 2019-12-06T21:27:35Z 2013 2013 Journal Article Hao, L., Chen, S., Xu, J., Tiwari, B., Fu, Z., Li, T., et al. (2013). Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with α,β-Unsaturated Imines. Organic Letters, 15(19), 4956–4959. https://hdl.handle.net/10356/104154 http://hdl.handle.net/10220/19452 10.1021/ol4021805 179767 en Organic letters © 2013 American Chemical Society
institution	Nanyang Technological University
building	NTU Library
country	Singapore
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry::Organic chemistry
spellingShingle	DRNTU::Science::Chemistry::Organic chemistry Hao, Lin Chen, Shaojin Xu, Jianfeng Tiwari, Bhoopendra Fu, Zhenqian Li, Tong Lim, Jieyan Chi, Robin Yonggui Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
description	Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Hao, Lin Chen, Shaojin Xu, Jianfeng Tiwari, Bhoopendra Fu, Zhenqian Li, Tong Lim, Jieyan Chi, Robin Yonggui
format	Article
author	Hao, Lin Chen, Shaojin Xu, Jianfeng Tiwari, Bhoopendra Fu, Zhenqian Li, Tong Lim, Jieyan Chi, Robin Yonggui
author_sort	Hao, Lin
title	Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
title_short	Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
title_full	Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
title_fullStr	Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
title_full_unstemmed	Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
title_sort	organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines
publishDate	2014
url	https://hdl.handle.net/10356/104154 http://hdl.handle.net/10220/19452
_version_	1681048880207101952

Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,​β-unsaturated imines

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Organocatalytic activation of alkylacetic esters as enolate precursors to react with α,β-unsaturated imines