Carbene and Acid Cooperative Catalytic Reactions of Aldehydes and o-Hydroxybenzhydryl Amines for Highly Enantioselective Access to Dihydrocoumarins

• Main Authors: Chen, Xingkuan, Song, Runjiang, Liu, Yingguo, Ooi, Chong Yih, Jin, Zhichao, Zhu, Tingshun, Wang, Hongling, Hao, Lin, Chi, Robin Yonggui
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Dihydrocoumarins; Enantioselective
• 在線閱讀: https://hdl.handle.net/10356/88490; http://hdl.handle.net/10220/44659
• 機構: Nanyang Technological University

A highly enantioselective method for quick access to dihydrocoumarins is reported. The reaction involves a cooperative catalytic process with carbene and in situ generated Brønsted acid as the catalysts. α-Chloro aldehyde and readily available and stable o-hydroxybenzhydryl amine substrates were use...