Carbene and Acid Cooperative Catalytic Reactions of Aldehydes and o-Hydroxybenzhydryl Amines for Highly Enantioselective Access to Dihydrocoumarins

• Main Authors: Chen, Xingkuan, Song, Runjiang, Liu, Yingguo, Ooi, Chong Yih, Jin, Zhichao, Zhu, Tingshun, Wang, Hongling, Hao, Lin, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Dihydrocoumarins; Enantioselective
• Online Access: https://hdl.handle.net/10356/88490; http://hdl.handle.net/10220/44659
• Institution: Nanyang Technological University

A highly enantioselective method for quick access to dihydrocoumarins is reported. The reaction involves a cooperative catalytic process with carbene and in situ generated Brønsted acid as the catalysts. α-Chloro aldehyde and readily available and stable o-hydroxybenzhydryl amine substrates were use...