Oxidative phosphorylation — an update on a new, essential target space for drug discovery in mycobacterium tuberculosis

• Main Authors: Foo, Caroline Shi-Yan, Pethe, Kevin, Lupien, Andréanne
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; Mycobacterium Tuberculosis; Energy Metabolism
• Online Access: https://hdl.handle.net/10356/138552
• Institution: Nanyang Technological University

New drugs with new mechanisms of action are urgently required to tackle the global tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor bedaquiline (Sirturo®), energy metabolism has become the subject of intense focus as a novel pathway to exploit for tuberculosis drug dev...