Insights into the role of hepatocyte PPARα activity in response to fasting

• Main Authors: Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fouché, Edwin, Michel, Géraldine, Lukowicz, Céline, Smati, Sarra, Marrot, Alain, Lasserre, Frédéric, Naylies, Claire, Batut, Aurélie, Viars, Fanny, Bertrand-Michel, Justine, Postic, Catherine, Loiseau, Nicolas, Wahli, Walter, Guillou, Hervé, Montagner, Alexandra
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Nuclear Receptor; PPARα
• Online Access: https://hdl.handle.net/10356/139085
• Institution: Nanyang Technological University

The liver plays a central role in the regulation of fatty acid metabolism. Hepatocytes are highly sensitive to nutrients and hormones that drive extensive transcriptional responses. Nuclear hormone receptors are key transcription factors involved in this process. Among these factors, PPARα is a crit...