Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins

Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins

A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a...

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Main Authors: Liang, Qiu-Ju, Jiang, Bing, Xu, Yun-He, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Chemical Reactions
Organic Compounds
Online Access:https://hdl.handle.net/10356/139183
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1391832020-05-18T02:27:54Z Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins Liang, Qiu-Ju Jiang, Bing Xu, Yun-He Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Chemical Reactions Organic Compounds A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups. 2020-05-18T02:27:39Z 2020-05-18T02:27:39Z 2018 Journal Article Liang, Q.-J., Jiang, B., Xu, Y.-H., & Loh, T.-P. (2018). Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins. The Journal of Organic Chemistry, 83(15), 8265-8271. doi:10.1021/acs.joc.8b00991 0022-3263 https://hdl.handle.net/10356/139183 10.1021/acs.joc.8b00991 29902382 2-s2.0-85048668406 15 83 8265 8271 en The Journal of Organic Chemistry © 2018 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Chemistry
Chemical Reactions
Organic Compounds
spellingShingle Science::Chemistry
Chemical Reactions
Organic Compounds
Liang, Qiu-Ju
Jiang, Bing
Xu, Yun-He
Loh, Teck-Peng
Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
description A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Liang, Qiu-Ju
Jiang, Bing
Xu, Yun-He
Loh, Teck-Peng
format Article
author Liang, Qiu-Ju
Jiang, Bing
Xu, Yun-He
Loh, Teck-Peng
author_sort Liang, Qiu-Ju
title Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
title_short Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
title_full Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
title_fullStr Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
title_full_unstemmed Palladium-catalyzed regioselective olefination of O-acetyl cyanohydrins
title_sort palladium-catalyzed regioselective olefination of o-acetyl cyanohydrins
publishDate 2020
url https://hdl.handle.net/10356/139183
_version_ 1681059621074108416

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