A catalytic and selective scissoring molecular tool for quadruplex nucleic acids

• Main Authors: Nadai, Matteo, Doria, Filippo, Scalabrin, Matteo, Pirota, Valentina, Grande, Vincenzo, Bergamaschi, Greta, Amendola, Valeria, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân, Richter, Sara N., Freccero, Mauro
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences; Hydroxyls; Genetics
• 在線閱讀: https://hdl.handle.net/10356/139320

A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry...