Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media

Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media

The hydration of α,β-unsaturated ketones with water proceeded efficiently in the presence of In(OTf)3 (20 mol%) in aqueous media to afford synthetically versatile β-hydroxyketones in moderate to good yields with good functional group compatibility. The method also can be extended to the hydroalkoxyl...

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Main Authors: Yun, Jin-Jin, Zhi, Man-Ling, Shi, Wen-Xiao, Chu, Xue-Qiang, Shen, Zhi-Liang, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Indium
Hydroxylation
Online Access:https://hdl.handle.net/10356/139332
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1393322020-05-19T02:20:07Z Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media Yun, Jin-Jin Zhi, Man-Ling Shi, Wen-Xiao Chu, Xue-Qiang Shen, Zhi-Liang Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Indium Hydroxylation The hydration of α,β-unsaturated ketones with water proceeded efficiently in the presence of In(OTf)3 (20 mol%) in aqueous media to afford synthetically versatile β-hydroxyketones in moderate to good yields with good functional group compatibility. The method also can be extended to the hydroalkoxylation of α,β-unsaturated ketones with various alcohols for the efficient synthesis of β-alkoxyketones as well as tetrahydrofuran derivatives. 2020-05-19T02:20:07Z 2020-05-19T02:20:07Z 2018 Journal Article Yun, J.-J., Zhi, M.-L., Shi, W.-X., Chu, X.-Q., Shen, Z.-L., & Loh, T.-P. (2018). Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media. Advanced Synthesis & Catalysis, 360(14), 2632-2637. doi:10.1002/adsc.201800301 1615-4150 https://hdl.handle.net/10356/139332 10.1002/adsc.201800301 2-s2.0-85047447015 14 360 2632 2637 en Advanced Synthesis and Catalysis © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Chemistry
Indium
Hydroxylation
spellingShingle Science::Chemistry
Indium
Hydroxylation
Yun, Jin-Jin
Zhi, Man-Ling
Shi, Wen-Xiao
Chu, Xue-Qiang
Shen, Zhi-Liang
Loh, Teck-Peng
Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
description The hydration of α,β-unsaturated ketones with water proceeded efficiently in the presence of In(OTf)3 (20 mol%) in aqueous media to afford synthetically versatile β-hydroxyketones in moderate to good yields with good functional group compatibility. The method also can be extended to the hydroalkoxylation of α,β-unsaturated ketones with various alcohols for the efficient synthesis of β-alkoxyketones as well as tetrahydrofuran derivatives.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Yun, Jin-Jin
Zhi, Man-Ling
Shi, Wen-Xiao
Chu, Xue-Qiang
Shen, Zhi-Liang
Loh, Teck-Peng
format Article
author Yun, Jin-Jin
Zhi, Man-Ling
Shi, Wen-Xiao
Chu, Xue-Qiang
Shen, Zhi-Liang
Loh, Teck-Peng
author_sort Yun, Jin-Jin
title Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
title_short Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
title_full Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
title_fullStr Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
title_full_unstemmed Indium(III)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
title_sort indium(iii)‐catalyzed hydration and hydroalkoxylation of α,β‐unsaturated ketones in aqueous media
publishDate 2020
url https://hdl.handle.net/10356/139332
_version_ 1681057727566053376

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