Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis

• Main Authors: Lee, Bei Shi, Pethe, Kevin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Molecular biology; Science::Biological sciences::Biochemistry; Tuberculosis; Promiscuous Targets
• Online Access: https://hdl.handle.net/10356/139344
• Institution: Nanyang Technological University

In the field of tuberculosis drug development, the term ‘promiscuous’ was coined to collectively describe targets that repeatedly show up in whole-cell screenings. With the current climate leaning towards the exclusion of these targets in future drug screens, this review discusses and clarifies misc...