Genome-wide association study of Parkinson’s disease in East Asians

• Main Authors: Foo, Jia Nee, Tan, Louis C., Irwan, Ishak D., Au, Wing-Lok, Low, Hui Qi, Prakash, Kumar-M., Azlina Ahmad-Annuar, Bei, Jinxin, Chan, Anne Y. Y., Chen, Chiung Mei, Chen, Yi-Chun, Chung, Sun Ju, Deng, Hao, Lim, Shen-Yang, Mok, Vincent, Pang, Hao, Pei, Zhong, Peng, Rong, Shang, Hui-Fang, Song, Kyuyoung, Tan, Ai Huey, Wu, Yih-Ru, Aung, Tin, Cheng, Ching-Yu, Chew, Fook Tim, Chew, Soo-Hong, Chong, Siow-Ann, Ebstein, Richard P., Lee, Jimmy, Saw, Seang-Mei, Seow, Adeline, Subramaniam, Mythily, Tai, E-Shyong, Vithana, Eranga N., Wong, Tien-Yin, Heng, Khai Koon, Meah, Wee-Yang, Khor, Chiea Chuen, Liu, Hong, Zheng, Furen, Liu, Jianjun, Tan, Eng-King
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Parkinson's Disease; Genetics
• Online Access: https://hdl.handle.net/10356/141184
• Institution: Nanyang Technological University

Genome-wide association studies (GWAS) on Parkinson’s disease (PD) have mostly been done in Europeans and Japanese. No study has been done in Han Chinese, which make up nearly a fifth of the world population. We conducted the first Han Chinese GWAS analysing a total of 22,729 subjects (5,125 PD case...