Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope

• Main Authors: Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences; Antibody; Therapeutic
• 在線閱讀: https://hdl.handle.net/10356/141659
• 機構: Nanyang Technological University

Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for co...