Structural and dynamics study of G-rich sequences relevant to genomic disorders

• Main Author: Maity, Arijit
• Other Authors: Chen Gang
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Chemistry; Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/141701
• Institution: Nanyang Technological University

Aberrant DNA repeat expansions have been linked to several (> 30) neurological and muscular disorders. In this dissertation, we present structural studies performed on two such repeat sequences GGGGCC and TGG using Nuclear Magnetic Resonance Spectroscopy (NMR) and other biophysical techniques....