Matrix-assisted laser desorption ionization mass spectrometry imaging of key proteins in corneal samples from lattice dystrophy patients with TGFBI-H626R and TGFBI-R124C mutations

• Main Authors: Venkatraman, Anandalakshmi, Hochart, Guillaume, Bonnel, David, Stauber, Jonathan, Shimmura, Shigeto, Rajamani, Lakshminaryanan, Pervushin, Konstantin, Mehta, Jodhbir S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Corneal Dystrophy; Matrix-assisted Laser Desorption/Ionization
• Online Access: https://hdl.handle.net/10356/141816
• Institution: Nanyang Technological University

Scope: The purpose of this study is to identify and visualize the spatial distribution of proteins present in amyloid corneal deposits of TGFBI‐CD patients using Mass Spectrometry Imaging (MSI) and compare it with healthy control cornea. Corneal Dystrophies (CD) constitute a group of genetically inh...