Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

• Main Authors: Venkatraman, Anandalakshmi, Duong-Thi, Minh-Dao, Pervushin, Konstantin, Ohlson, Sten, Mehta, Jodhbir Singh
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Biological sciences; Corneal Dystrophy; Weak Affinity Chromatography
• 在線閱讀: https://hdl.handle.net/10356/147334
• 機構: Nanyang Technological University

Corneal dystrophies are a group of genetically inherited disorders with mutations in the TGFBI gene affecting the Bowman's membrane and the corneal stroma. The mutant TGFBIp is highly aggregation-prone and is deposited in the cornea. Depending on the type of mutation the protein deposits may va...