Asperidine B : total synthesis and structure correction

• Main Authors: Waddell, Lachlan J. N., Watts, Olivia F. B., Saetang, Praphatsorn, Rukachaisirikul, Vatcharin, Bates, Roderick Wayland
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Piperidine; Pyrrolidine
• Online Access: https://hdl.handle.net/10356/141978; https://doi.org/10.21979/N9/OD7MHF
• Institution: Nanyang Technological University

A synthesis of the proposed structure of asperidine B is reported, involving a tandem hydroformylation-condensation reaction, a diastereoselective dihydroxylation and the addition of an organozinc reagent to an iminium ion. As the spectroscopic data for the synthetic material is not in agreement wit...