Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

• Main Authors: Lim, Xin-Ni, Shan, Chao, Marzinek, Jan K., Dong, Hongping, Ng, Thiam Seng, Ooi, Justin Seng Geap, Fibriansah, Guntur, Wang, Jiaqi, Verma, Chandra Shekhar, Bond, Peter John, Shi, Pei-Yong, Lok, Shee-mei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Dengue Virus; DENV2
• Online Access: https://hdl.handle.net/10356/142196
• Institution: Nanyang Technological University

The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature...