Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

• المؤلفون الرئيسيون: Lim, Xin-Ni, Shan, Chao, Marzinek, Jan K., Dong, Hongping, Ng, Thiam Seng, Ooi, Justin Seng Geap, Fibriansah, Guntur, Wang, Jiaqi, Verma, Chandra Shekhar, Bond, Peter John, Shi, Pei-Yong, Lok, Shee-mei
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Biological sciences; Dengue Virus; DENV2
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142196

The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature...