Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

• Main Authors: Tan, Chin Hong, Low, Kathy A., Chiarelli, Antonio M., Fletcher, Mark A., Navarra, Riccardo, Burzynska, Agnieszka Z., Kong, Tania S., Zimmerman, Benjamin, Maclin, Edward L., Sutton, Bradley P., Gratton, Gabriele, Fabiani, Monica
• Other Authors: School of Social Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Social sciences::Psychology; Aging; Fluid Abilities
• Online Access: https://hdl.handle.net/10356/142979
• Institution: Nanyang Technological University

Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is as...