Investigating ERO1α, IDO1 and MHC Class I : potential proteins that can be manipulated to change the tumour microenvironment from ‘cold’ to ‘hot’

• Main Author: Peck, Jia Yi
• Other Authors: Sze Siu Kwan
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/143295
• Institution: Nanyang Technological University

ERO1α, a cancer-associated protein, and IDO1, an immunomodulatory enzyme, have been shown to be associated with the expression of MHC Class I proteins. Previous study done by our lab that showed ERO1α association with hypoxic tumour progression, also had preliminary data indicating that under hypoxi...