Biomimicking fiber platform with tunable stiffness to study mechanotransduction reveals stiffness enhances oligodendrocyte differentiation but impedes myelination through YAP-dependent regulation

• Main Authors: Ong, William, Marinval, Nicolas, Lin, Junquan, Nai, Mui Hoon, Chong, Yee-Song, Pinese, Coline, Sajikumar, Sreedharan, Lim, Chwee Teck, Ffrench-Constant, Charles, Bechler, Marie E., Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; Biomaterials; Myelination
• Online Access: https://hdl.handle.net/10356/143758
• Institution: Nanyang Technological University

A key hallmark of many diseases, especially those in the central nervous system (CNS), is the change in tissue stiffness due to inflammation and scarring. However, how such changes in microenvironment affect the regenerative process remains poorly understood. Here, we report a biomimicking fiber pla...