Controlled reduction of carboxamides to alcohols or amines by zinc hydrides

• Main Authors: Ong, Derek Yiren, Yen, Zhihao, Yoshii, Asami, Imbernon, Julia Revillo, Takita, Ryo, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Alcohols; Amides
• Online Access: https://hdl.handle.net/10356/144604
• Institution: Nanyang Technological University

New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2 ). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives ami...