Investigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient mice

Investigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient mice

Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroida...

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Bibliographic Details
Main Authors: Ho, Sze Yuan, Kwan, Yuet Ping, Qiu, Beiying, Tan, Alison, Murray, Hannah Louise, Barathi, Veluchamy Amutha, Tan, Nguan Soon, Cheung, Gemmy Chui Ming, Wong, Tien Yin, Wahli, Walter, Wang, Xiaomeng
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2020
Subjects:
Science::Medicine
PPARβ/δ
Angiogenesis
Online Access:https://hdl.handle.net/10356/144724
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Institution: Nanyang Technological University
Language: English
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Summary:Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.

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