Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice

• Main Authors: Tan, Mark Wei Yi, Sng, Ming Keat, Cheng, Hong Sheng, Low, Zun Siong, Leong, Benjamin Jia Juin, Chua, Damien, Tan, Eddie Han Pin, Chan, Jeremy Soon Kiat, Yip, Yun Sheng, Lee, Yin Hao, Pal, Mintu, Wang, Xiaomeng, Wahli, Walter, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; B Raf; Kinasehydrogen Peroxide
• Online Access: https://hdl.handle.net/10356/144773
• Institution: Nanyang Technological University

The incidence of nonmelanoma skin cancer (NMSC) has been increasing worldwide. Most studies have highlighted the importance of cancer-associated fibroblasts (CAFs) in NMSC progression. However much less is known about the communication between normal fibroblasts and epithelia; disruption of this com...