Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes

• Main Authors: Chilambi, Gayatri Shankar, Hinks, Jamie, Matysik, Artur, Zhu, Xinyi, Choo, Pei Yi, Liu, Xianghui, Chan-Park, Mary B., Bazan, Guillermo C., Kline, Kimberly A., Rice, Scott A.
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Enterococcus Faecalis; Conjugated Oligolectrolytes
• Online Access: https://hdl.handle.net/10356/145240
• Institution: Nanyang Technological University

Conjugated oligoelectrolytes (COEs) are emerging antimicrobials with broad spectrum activity against Gram positive and Gram negative bacteria as well as fungi. Our previous in vitro evolution studies using Enterococcus faecalis grown in the presence of two related COEs (COE1-3C and COE1-3Py) led to...