Towards understanding and applications of antisense oligonucleotides

• Main Author: Nguyen, Le Tuan Anh
• Other Authors: Phan Anh Tuan
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Medicine::Pharmacy::Pharmaceutical technology; Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/145300
• Institution: Nanyang Technological University

Antisense oligonucleotides (ASOs), which are synthetic single-stranded nucleic acids, could enter living cells, hybridize to RNAs and inhibit gene expression. This approach could potentially lead to desired alterations of cellular characteristics, and has been under intensive investigations. This th...