Development of ratiometric fluorescent pH nanoprobe to study endocytic uptake pathways of antisense oligonucleotides

• Main Author: Liew, Donn Hou Feng
• Other Authors: Phan Anh Tuan
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences::Biophysics; Science::Physics::Optics and light
• Online Access: https://hdl.handle.net/10356/148512
• Institution: Nanyang Technological University

Anti-sense oligonucleotides (ASOs) are single short strands of synthetic DNA/RNA designed to complement specific RNA sequences. Antisense therapy as a treatment option has received widespread consideration as only knowledge of a nucleotide sequence is necessary for drug design. However, one challeng...