Development of ratiometric fluorescent pH nanoprobe to study endocytic uptake pathways of antisense oligonucleotides

• المؤلف الرئيسي: Liew, Donn Hou Feng
• مؤلفون آخرون: Phan Anh Tuan
• التنسيق: Final Year Project
• اللغة: English
• منشور في: Nanyang Technological University 2021
• الموضوعات: Science::Biological sciences::Biophysics; Science::Physics::Optics and light
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148512
• المؤسسة: Nanyang Technological University

Anti-sense oligonucleotides (ASOs) are single short strands of synthetic DNA/RNA designed to complement specific RNA sequences. Antisense therapy as a treatment option has received widespread consideration as only knowledge of a nucleotide sequence is necessary for drug design. However, one challeng...