Development of mucus-penetrating antibiotic and quorum sensing inhibitor nanoparticle complex for bronchiectasis therapy

• Main Author: Tran, The Thien
• Other Authors: Kunn Hadinoto Ong
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Engineering::Chemical engineering::Biochemical engineering; Engineering::Nanotechnology
• Online Access: https://hdl.handle.net/10356/145374
• Institution: Nanyang Technological University

Bronchiectasis is a chronic respiratory disease characterized by permanent and irreversible dilatation of the airways caused by a vicious cycle of infection and inflammation, leading to the loss of lung function, morbidity, and mortality. Early results suggested inhaled ciprofloxacin (CIP) as a prom...