Ligand-specific factors influencing GLP-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells

• Main Authors: Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa, Ivan R., Jr., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Glucagon-like Peptide-1; Exendin-4
• Online Access: https://hdl.handle.net/10356/145775
• Institution: Nanyang Technological University

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes. Here, we have evaluated how different factors comb...