Persistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetes

• Main Authors: Marselli, Lorella, Piron, Anthony, Suleiman, Mara, Colli, Maikel L., Yi, Xiaoyan, Khamis, Amna, Carrat, Gaelle R., Rutter, Guy A., Bugliani, Marco, Giusti, Laura, Ronci, Maurizio, Ibberson, Mark, Turatsinze, Jean-Valery, Boggi, Ugo, de Simone, Paolo, de Tata, Vincenzo, Lopes, Miguel, Nasteska, Daniela, de Luca, Carmela, Tesi, Marta, Bosi, Emanuele, Singh, Pratibha, Campani, Daniela, Schulte, Anke M., Solimena, Michele, Hecht, Peter, Rady, Brian, Bakaj, Ivona, Pocai, Alessandro, Norquay, Lisa, Thorens, Bernard, Canouil, Mickaël, Froguel, Philippe, Eizirik, Decio L., Cnop, Miriam, Marchetti, Piero
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Type 2 Diabetes; Lipoglucotoxicity
• Online Access: https://hdl.handle.net/10356/145995
• Institution: Nanyang Technological University

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient damage, and explore the relationships with T2D islet traits....