DNA methylation and lipid metabolism : an EWAS of 226 metabolic measures

• Main Authors: Gomez-Alonso, Monica del C., Kretschmer, Anja, Wilson, Rory, Pfeiffer, Liliane, Karhunen, Ville, Seppälä, Ilkka, Zhang, Weihua, Mittelstraß, Kirstin, Wahl, Simone, Matias-Garcia, Pamela R., Prokisch, Holger, Horn, Sacha, Meitinger, Thomas, Serrano-Garcia, Luis R., Sebert, Sylvain, Raitakari, Olli, Loh, Marie, Rathmann, Wolfgang, Müller-Nurasyid, Martina, Herder, Christian, Roden, Michael, Hurme, Mikko, Jarvelin, Marjo-Riitta, Ala-Korpela, Mika, Kooner, Jaspal S., Peters, Annette, Lehtimäki, Terho, Chambers, John Campbell, Gieger, Christian, Kettunen, Johannes, Waldenberger, Melanie
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; CpG Site; VLDL
• Online Access: https://hdl.handle.net/10356/146162
• Institution: Nanyang Technological University

Background: The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation and the lipid compositions and lipid concentrations of lipoprotein sizes have bee...