CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

• Main Authors: Langebäck, Anette, Bacanu, Smaranda, Laursen, Henriette, Mout, Lisanne, Seki, Takahiro, Erkens-Schulze, Sigrun, Ramos, Anderson Daniel, Berggren, Anna, Cao, Yihai, Hartman, Johan, van Weerden, Wytske, Bergh, Jonas, Nordlund, Pär, Lööf, Sara
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Biological sciences; Breast Cancer; Tumour Biomarkers
• 在線閱讀: https://hdl.handle.net/10356/146225

The use of taxanes has for decades been crucial for treatment of several cancers. A major limitation of these therapies is inherent or acquired drug resistance. A key to improved outcome of taxane-based therapies is to develop tools to predict and monitor drug efficacy and resistance in the clinical...