Investigating the solid-state assembly of pharmaceutically-relevant N,N-dimethyl-O-thiocarbamates in the absence of labile hydrogen bonds

• المؤلفون الرئيسيون: Tan, Davin, Ng, Zi Xuan, Ganguly, Rakesh, Li, Yongxin, Soo, Han Sen, Sharmarke Mohamed, García, Felipe
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Engineering; Thiocarbamates; Hydrogen Bonds
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/146290
• المؤسسة: Nanyang Technological University

There are many active pharmaceutical ingredients that lack N-H, O-H and S-H hydrogen-bond donor functional groups. N,N-disubstituted O-thiocarbamates are examples of molecules that display such a feature. Despite the desirable medicinal properties displayed by some N,N-disubstituted O-thiocarbamates...