An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy

• Main Authors: Feng, Lili, Liu, Bin, Xie, Rui, Wang, Dongdong, Qian, Cheng, Zhou, Weiqiang, Liu, Jiawei, Jana, Deblin, Yang, Piaoping, Zhao, Yanli
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; Chemodynamic Theraphy; Nanozyme
• 在線閱讀: https://hdl.handle.net/10356/146313
• 機構: Nanyang Technological University

The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels of hydrogen peroxide (H2O2) dramatically limits the antitumor efficiency by monotherapy. Herein, a novel TME-modulated nanozyme employing tin ferrite (SnFe2O4, abbreviated as...