Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme

• Main Authors: Cao, Changyu, Yang, Nan, Su, Yan, Zhang, Zheye, Wang, Chenxi, Song, Xuejiao, Chen, Peng, Wang, Wenjun, Dong, Xiaochen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Science::Medicine; Ferroptosis; Nanozyme
• Online Access: https://hdl.handle.net/10356/161630
• Institution: Nanyang Technological University

Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive...