Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme
Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/161630 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-161630 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-1616302023-03-05T16:53:01Z Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme Cao, Changyu Yang, Nan Su, Yan Zhang, Zheye Wang, Chenxi Song, Xuejiao Chen, Peng Wang, Wenjun Dong, Xiaochen Lee Kong Chian School of Medicine (LKCMedicine) School of Chemical and Biomedical Engineering Engineering::Chemical engineering Science::Medicine Ferroptosis Nanozyme Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu-Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically. Ministry of Education (MOE) Submitted/Accepted version The work was supported by NNSF of China (62120106002, 22175089, 61935004), Jiangsu Province Policy Guidance Plan (BZ2019014), Jiangsu Provincial key research and development plan (BE2021711), NSF of Ningbo (202003N40448), NSF of Shandong Province (ZR2020KB018), “Taishan scholars” construction special fund of Shandong Province, and AcRF Tier-2 grant (MOE2019-T2-2-004) from Ministry of Education of Singapore. 2022-09-12T08:43:26Z 2022-09-12T08:43:26Z 2022 Journal Article Cao, C., Yang, N., Su, Y., Zhang, Z., Wang, C., Song, X., Chen, P., Wang, W. & Dong, X. (2022). Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme. Advanced Materials, 34(29), e2203236-. https://dx.doi.org/10.1002/adma.202203236 0935-9648 https://hdl.handle.net/10356/161630 10.1002/adma.202203236 35562328 2-s2.0-85131239747 29 34 e2203236 en MOE2019-T2-2-004 Advanced Materials © 2022 Wiley-VCH GmbH. All rights reserved. This is the peer reviewed version of the following article: Cao, C., Yang, N., Su, Y., Zhang, Z., Wang, C., Song, X., Chen, P., Wang, W. & Dong, X. (2022). Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme. Advanced Materials, 34(29), e2203236-. https://dx.doi.org/10.1002/adma.202203236, which has been published in final form at https://dx.doi.org/10.1002/adma.202203236. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NTU Library |
| collection |
DR-NTU |
| language |
English |
| topic |
Engineering::Chemical engineering Science::Medicine Ferroptosis Nanozyme |
| spellingShingle |
Engineering::Chemical engineering Science::Medicine Ferroptosis Nanozyme Cao, Changyu Yang, Nan Su, Yan Zhang, Zheye Wang, Chenxi Song, Xuejiao Chen, Peng Wang, Wenjun Dong, Xiaochen Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| description |
Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu-Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1-tumor-bearing mice. The underlying working mechanism is revealed both experimentally and theoretically. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Cao, Changyu Yang, Nan Su, Yan Zhang, Zheye Wang, Chenxi Song, Xuejiao Chen, Peng Wang, Wenjun Dong, Xiaochen |
| format |
Article |
| author |
Cao, Changyu Yang, Nan Su, Yan Zhang, Zheye Wang, Chenxi Song, Xuejiao Chen, Peng Wang, Wenjun Dong, Xiaochen |
| author_sort |
Cao, Changyu |
| title |
Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| title_short |
Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| title_full |
Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| title_fullStr |
Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| title_full_unstemmed |
Starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| title_sort |
starvation, ferroptosis, and prodrug therapy synergistically enabled by a cytochrome c oxidase like nanozyme |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/161630 |
| _version_ |
1759857645145030656 |