Critical role for cold shock protein YB-1 in cytokinesis

• Main Authors: Mehta, Sunali, Algie, Michael, Al-Jabry, Tariq, McKinney, Cushla, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Ma, Weini, Zhang, Jessie, Bartolec, Tara K., Masamsetti, V. Pragathi, Parker, Kim, Henderson, Luke, Gould, Maree L., Bhatia, Puja, Harfoot, Rhodri, Chircop, Megan, Kleffmann, Torsten, Cohen, Scott B., Woolley, Adele G., Cesare, Anthony J., Braithwaite, Antony
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; YB-1; Cold Shock Protein
• Online Access: https://hdl.handle.net/10356/146593
• Institution: Nanyang Technological University

High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation and progression. However, the precise mechanism by which YB-1 regulates proliferation is unknown. Here, we found that YB-1 depletion in several cancer cell lines and in immor...