Targeting the bacterial epitranscriptome for antibiotic development : discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors

• Main Authors: Zhong, Wenhe, Koay, Ann, Ngo, Anna, Li, Yan, Nah, Qianhui, Wong, Yee Hwa, Chionh, Yok Hian, Ng, Hui Qi, Koh-Stenta, Xiaoying, Poulsen, Anders, Foo, Klement, McBee, Megan, Choong, Meng Ling, El Sahili, Abbas, Kang, Congbao, Matter, Alex, Lescar, Julien, Hill, Jeffrey, Dedon, Peter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; tRNA Modification; High-throughput Screening
• Online Access: https://hdl.handle.net/10356/146983
• Institution: Nanyang Technological University

Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(N1G37) methyltransferase (TrmD), which is conserved and essential in many bacterial pathogens. Here we d...