Iridium-promoted deoxyglycoside synthesis : stereoselectivity and mechanistic insight

• Main Authors: Pal, Kumar Bhaskar, Guo, Aoxin, Das, Mrinmoy, Lee, Jiande, Báti, Gábor, Yip, Benjamin Rui Peng, Loh, Teck-Peng, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Stereoselective O-glycosylation; Ir(I)-catalyst
• Online Access: https://hdl.handle.net/10356/147077
• Institution: Nanyang Technological University

Herein, we devised a method for stereoselective O-glycosylation using an Ir(I)-catalyst which enables both hydroalkoxylation and nucleophilic substitution of glycals with varying substituents at the C3 position. In this transformation, 2-deoxy-α-O-glycosides were acquired when glycals equipped with...