A polycaprolactone-β-tricalcium phosphate-heparan sulphate device for cranioplasty

• Main Authors: Le, Bach Quang, Rai, Bina, Lim, Zophia Xue Hui, Tan, Tuan Chun, Lin, Tingxuan, Lee, Jaslyn Jie Lin, Murali, Sadasivam, Teoh, Swee Hin, Nurcombe, Victor, Cool, Simon McKenzie
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Chemical engineering; Calvarial Defect; Glycosaminoglycans
• Online Access: https://hdl.handle.net/10356/147126
• Institution: Nanyang Technological University

Cranioplasty is a surgical procedure used to treat a bone defect or deformity in the skull. To date, there is little consensus on the standard-of-care for graft materials used in such a procedure. Graft materials must have sufficient mechanical strength to protect the underlying brain as well as the ability to integrate and support new bone growth. Also, the ideal graft material should be individually customized to the contours of the defect to ensure a suitable aesthetic outcome for the patient.