Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period

Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period

The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis...

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Bibliographic Details
Main Authors: Octavia, Sophie, Koh, Tse Hsien, Ng, Oon Tek, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Lin, Raymond T. P., Teo, Jeanette W. P.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Enterobacter
Enterobacteriaceae
Online Access:https://hdl.handle.net/10356/147810
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Institution: Nanyang Technological University
Language: English
Description
Summary:The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected.

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