Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period

Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period

The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis...

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Main Authors: Octavia, Sophie, Koh, Tse Hsien, Ng, Oon Tek, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Lin, Raymond T. P., Teo, Jeanette W. P.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Enterobacter
Enterobacteriaceae
Online Access:https://hdl.handle.net/10356/147810
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1478102023-03-05T16:47:55Z Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Enterobacter Enterobacteriaceae The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected. Ministry of Education (MOE) National Medical Research Council (NMRC) Published version Grant support was provided by the NMRC Clinician-Scientist Individual ResearchGrant (NMRC/CIRG/1463/2016), Singapore Ministry of Education Academic ResearchFund Tier 2 grant: New Delhi Metallo-Beta-Lactamase: A global multicenter, whole-genome study (MOE2015-T2-2-096), NMRC Collaborative Grant: Collaborative SolutionsTargeting Antimicrobial Resistance Threats in Health Systems (CoSTAR-HS) (NMRCCGAug16C005), and NMRC Clinician Scientist Award (NMRC/CSA-INV/0002/2016). 2021-04-13T07:23:04Z 2021-04-13T07:23:04Z 2020 Journal Article Octavia, S., Koh, T. H., Ng, O. T., Marimuthu, K., Venkatachalam, I., Lin, R. T. P. & Teo, J. W. P. (2020). Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period. Antimicrobial Agents and Chemotherapy, 64(8). https://dx.doi.org/10.1128/AAC.00510-20 0066-4804 https://hdl.handle.net/10356/147810 10.1128/AAC.00510-20 32482676 2-s2.0-85088610161 8 64 en NMRC/CIRG/1463/2016 MOE2015-T2-2-096 NMRCCGAug16C005 NMRC/CSA-INV/0002/2016 Antimicrobial Agents and Chemotherapy © 2020 American Society for Microbiology. All Rights Reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Enterobacter
Enterobacteriaceae
spellingShingle Science::Medicine
Enterobacter
Enterobacteriaceae
Octavia, Sophie
Koh, Tse Hsien
Ng, Oon Tek
Marimuthu, Kalisvar
Venkatachalam, Indumathi
Lin, Raymond T. P.
Teo, Jeanette W. P.
Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
description The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Octavia, Sophie
Koh, Tse Hsien
Ng, Oon Tek
Marimuthu, Kalisvar
Venkatachalam, Indumathi
Lin, Raymond T. P.
Teo, Jeanette W. P.
format Article
author Octavia, Sophie
Koh, Tse Hsien
Ng, Oon Tek
Marimuthu, Kalisvar
Venkatachalam, Indumathi
Lin, Raymond T. P.
Teo, Jeanette W. P.
author_sort Octavia, Sophie
title Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
title_short Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
title_full Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
title_fullStr Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
title_full_unstemmed Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
title_sort genomic study of blaimi-positive enterobacter cloacae complex in singapore over a five-year study period
publishDate 2021
url https://hdl.handle.net/10356/147810
_version_ 1759853822691246080

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