Structural and biochemical study of Candida albicans polarisomal proteins

Structural and biochemical study of Candida albicans polarisomal proteins

The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of n...

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Bibliographic Details
Main Author: Loh, Zhi Yang
Other Authors: Gao Yonggui
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2021
Subjects:
Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
Online Access:https://hdl.handle.net/10356/147880
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Institution: Nanyang Technological University
Language: English
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Summary:The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of nucleation promoting factor Aip5 with its S. cerevisiae homolog revealed the difference in actin-binding loop flexibility, which may account for their differential actin-binding affinities reported in literature.

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