Structural and biochemical study of Candida albicans polarisomal proteins

Structural and biochemical study of Candida albicans polarisomal proteins

The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of n...

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Main Author: Loh, Zhi Yang
Other Authors: Gao Yonggui
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2021
Subjects:
Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
Online Access:https://hdl.handle.net/10356/147880
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1478802023-02-28T18:33:13Z Structural and biochemical study of Candida albicans polarisomal proteins Loh, Zhi Yang Gao Yonggui School of Biological Sciences NTU Institute of Structural Biology ygao@ntu.edu.sg Science::Biological sciences::Biochemistry Science::Biological sciences::Microbiology The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of nucleation promoting factor Aip5 with its S. cerevisiae homolog revealed the difference in actin-binding loop flexibility, which may account for their differential actin-binding affinities reported in literature. Doctor of Philosophy 2021-04-14T06:02:31Z 2021-04-14T06:02:31Z 2020 Thesis-Doctor of Philosophy Loh, Z. Y. (2020). Structural and biochemical study of Candida albicans polarisomal proteins. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/147880 https://hdl.handle.net/10356/147880 10.32657/10356/147880 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
spellingShingle Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
Loh, Zhi Yang
Structural and biochemical study of Candida albicans polarisomal proteins
description The polarisome is a multi-protein complex involved in the assembly of actin cytoskeleton during polarised hyphae growth in pathogenic yeast C. albicans. In this thesis, we present the crystal structure of C. albicans polarisomal protein Aip5 (786-896) at 2.65 Å resolution. Structural comparison of nucleation promoting factor Aip5 with its S. cerevisiae homolog revealed the difference in actin-binding loop flexibility, which may account for their differential actin-binding affinities reported in literature.
author2 Gao Yonggui
author_facet Gao Yonggui
Loh, Zhi Yang
format Thesis-Doctor of Philosophy
author Loh, Zhi Yang
author_sort Loh, Zhi Yang
title Structural and biochemical study of Candida albicans polarisomal proteins
title_short Structural and biochemical study of Candida albicans polarisomal proteins
title_full Structural and biochemical study of Candida albicans polarisomal proteins
title_fullStr Structural and biochemical study of Candida albicans polarisomal proteins
title_full_unstemmed Structural and biochemical study of Candida albicans polarisomal proteins
title_sort structural and biochemical study of candida albicans polarisomal proteins
publisher Nanyang Technological University
publishDate 2021
url https://hdl.handle.net/10356/147880
_version_ 1759853554560925696

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