Protein-based artificial nanosystems in cancer therapy

Proteins, like actors, play different roles in specific applications. In the past decade, significant achievements have been made in protein‐engineered biomedicine for cancer therapy. Certain proteins such as human serum albumin, working as carriers for drug/photosensitizer delivery, have entered cl...

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Main Authors: Zhang, Nan, Mei, Kun, Guan, Ping, Hu, Xiaoling, Zhao, Yanli
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/148134
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1481342023-02-28T19:56:48Z Protein-based artificial nanosystems in cancer therapy Zhang, Nan Mei, Kun Guan, Ping Hu, Xiaoling Zhao, Yanli School of Physical and Mathematical Sciences Science::Chemistry Nanomedicine Cancer Therapy Proteins, like actors, play different roles in specific applications. In the past decade, significant achievements have been made in protein‐engineered biomedicine for cancer therapy. Certain proteins such as human serum albumin, working as carriers for drug/photosensitizer delivery, have entered clinical use due to their long half‐life, biocompatibility, biodegradability, and inherent nonimmunogenicity. Proteins with catalytic abilities are promising as adjuvant agents for other therapeutic modalities or as anticancer drugs themselves. These catalytic proteins are usually defined as enzymes with high biological activity and substrate specificity. However, clinical applications of these kinds of proteins remain rare due to protease‐induced denaturation and weak cellular permeability. Based on the characteristics of different proteins, tailor‐made protein‐based nanosystems could make up for their individual deficiencies. Therefore, elaborately designed protein‐based nanosystems, where proteins serve as drug carriers, adjuvant agents, or therapeutic drugs to make full use of their intrinsic advantages in cancer therapy, are reviewed. Up‐to‐date progress on research in the field of protein‐based nanomedicine is provided. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Accepted version The authors are grateful for the financial support of China Scholarship Council, the National Nature Science Foundation of China (No. 51433008), the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (No. A1883c0005), and the Singapore National Research Foundation Investigatorship (No. NRF-NRFI2018-03). 2021-04-19T07:48:13Z 2021-04-19T07:48:13Z 2020 Journal Article Zhang, N., Mei, K., Guan, P., Hu, X. & Zhao, Y. (2020). Protein-based artificial nanosystems in cancer therapy. Small, 16(23), 1907256-. https://dx.doi.org/10.1002/smll.201907256 1613-6829 https://hdl.handle.net/10356/148134 10.1002/smll.201907256 23 16 1907256 en Small This is the peer reviewed version of the following article: Zhang, N., Mei, K., Guan, P., Hu, X. & Zhao, Y. (2020). Protein-based artificial nanosystems in cancer therapy. Small, 16(23), 1907256-. https://dx.doi.org/10.1002/smll.201907256, which has been published in final form at https://doi.org/10.1002/smll.201907256. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Nanomedicine
Cancer Therapy
spellingShingle Science::Chemistry
Nanomedicine
Cancer Therapy
Zhang, Nan
Mei, Kun
Guan, Ping
Hu, Xiaoling
Zhao, Yanli
Protein-based artificial nanosystems in cancer therapy
description Proteins, like actors, play different roles in specific applications. In the past decade, significant achievements have been made in protein‐engineered biomedicine for cancer therapy. Certain proteins such as human serum albumin, working as carriers for drug/photosensitizer delivery, have entered clinical use due to their long half‐life, biocompatibility, biodegradability, and inherent nonimmunogenicity. Proteins with catalytic abilities are promising as adjuvant agents for other therapeutic modalities or as anticancer drugs themselves. These catalytic proteins are usually defined as enzymes with high biological activity and substrate specificity. However, clinical applications of these kinds of proteins remain rare due to protease‐induced denaturation and weak cellular permeability. Based on the characteristics of different proteins, tailor‐made protein‐based nanosystems could make up for their individual deficiencies. Therefore, elaborately designed protein‐based nanosystems, where proteins serve as drug carriers, adjuvant agents, or therapeutic drugs to make full use of their intrinsic advantages in cancer therapy, are reviewed. Up‐to‐date progress on research in the field of protein‐based nanomedicine is provided.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhang, Nan
Mei, Kun
Guan, Ping
Hu, Xiaoling
Zhao, Yanli
format Article
author Zhang, Nan
Mei, Kun
Guan, Ping
Hu, Xiaoling
Zhao, Yanli
author_sort Zhang, Nan
title Protein-based artificial nanosystems in cancer therapy
title_short Protein-based artificial nanosystems in cancer therapy
title_full Protein-based artificial nanosystems in cancer therapy
title_fullStr Protein-based artificial nanosystems in cancer therapy
title_full_unstemmed Protein-based artificial nanosystems in cancer therapy
title_sort protein-based artificial nanosystems in cancer therapy
publishDate 2021
url https://hdl.handle.net/10356/148134
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