Carbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihyropyrimidin-4-ones

• Main Authors: Maiti, Rakesh, Xu, Jun, Yan, Jia-Lei, Mondal, Bivas, Yang, Xing, Chai, Huifang, Hao, Lin, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Addition Reactions; Catalysis
• Online Access: https://hdl.handle.net/10356/148227
• Institution: Nanyang Technological University

A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions is reported. The key steps of our reactions involve the formation of two carbon–nitrogen bonds in a highly regio-selective manner. A variety of sulphur-containing 5,6-dihydropyrimidin-4-ones are obtained...